
Tadalafil
RxLonger-lasting ED treatment
A prescription PDE5 inhibitor known for its longer duration of action, which may offer greater flexibility around timing.
Explore tadalafil →Men's sexual health
Talk privately with a licensed NORBU MD physician about erectile dysfunction and available prescription treatment options — entirely online.
$29 physician visit · 100% online · Board-certified physicians · Discreet care
Prescription treatment requires physician evaluation and is provided only when clinically appropriate. Medication cost is separate.

You're not the only one
Erectile dysfunction can happen for many reasons — including blood flow, medications, stress, hormones, underlying health conditions and other factors.
A physician can help evaluate what may be contributing and discuss treatment options appropriate for you.
ED treatments
Different ED medications have different characteristics. Your NORBU MD physician can help determine which treatment approach may be appropriate based on your health, preferences and medical history.

Longer-lasting ED treatment
A prescription PDE5 inhibitor known for its longer duration of action, which may offer greater flexibility around timing.
Explore tadalafil →
On-demand ED treatment
A well-established prescription PDE5 inhibitor generally used before anticipated sexual activity.
Explore sildenafil →
Two established ED ingredients. One physician-guided treatment option.
NORBU MD may offer a customized treatment option combining sildenafil and tadalafil when prescribed by a physician and clinically appropriate.
A customized (compounded) formulation combining tadalafil and sildenafil is not an FDA-approved combination drug product. Compounded medications are prepared by a pharmacy for an individual patient and are not reviewed by the FDA for safety, effectiveness or manufacturing quality in the way FDA-approved products are. Availability depends on physician judgment and clinical appropriateness.
Explore combination treatment →Exploring a treatment tells your physician what you're interested in. It does not mean a prescription will be written. Treatment is subject to physician evaluation and clinical appropriateness.
Compare options
General positioning
Longer duration of action
Often considered by patients who
Prefer more flexibility around timing
General positioning
Shorter-acting, on-demand approach
Often considered by patients who
Prefer treatment closer to anticipated sexual activity
General positioning
Customized combination treatment
Often considered by patients who
May be considered only when prescribed by a physician who determines it is medically appropriate
This comparison is educational. It is not a ranking, and it does not indicate that any option is stronger, safer or better than another — or that any treatment is appropriate for you. Combination treatment may be considered only when prescribed by a physician who determines it is medically appropriate.
Not sure? Let a physician help →How treatment works
PDE5 inhibitors such as sildenafil and tadalafil can support erectile function by affecting the pathway involved in blood flow to penile tissue during sexual stimulation.

The bigger picture
Erectile function depends on circulation, nerves, hormones and overall health. That's one reason NORBU MD puts the physician before the prescription.
This information is educational and is not a diagnosis. Only a licensed physician who has evaluated you can discuss what may be contributing to your symptoms.
Start with a physician →Private. Simple. Online.
$29Physician visit
For $29, meet privately online with a licensed NORBU MD physician to discuss your symptoms, medical history and ED treatment options.
Start my private visit →100% online · Board-certified physicians · Discreet care · Ongoing support
Medication and laboratory costs, if applicable, are separate.
Safety matters
Sildenafil and tadalafil can interact with certain medications and may not be appropriate for patients with certain health conditions. Your physician reviews your full medication list and medical history before any treatment decision.
Every prescription medication has risks, warnings, contraindications and possible interactions. Review the full prescribing information for any product prescribed to you, and tell your NORBU MD physician about all medications, supplements and health conditions before starting or changing treatment. Seek medical care promptly for any symptom that concerns you.

The NORBU standard
Sexual health is medical care. NORBU MD starts with a physician who evaluates your health and helps determine which treatment options may be appropriate for you.
Questions
ED can have many contributors, including blood flow and cardiovascular health, diabetes and metabolic conditions, medications, hormonal factors, stress and anxiety, alcohol or substance use, neurological factors and other health conditions. Often more than one factor is involved, which is why an evaluation matters.
Occasional difficulty with erections is common, and persistent ED is a common medical concern in adult men. It is not a character flaw. It is a health issue that can be evaluated and, in many cases, treated.
Sildenafil and tadalafil are PDE5 inhibitors. They act on the pathway involved in blood flow to penile tissue during sexual stimulation, supporting the body's natural erectile response. They do not create an erection on their own.
Both are PDE5 inhibitors, but they differ in how long they remain active and how they are typically used. Sildenafil is generally used before anticipated sexual activity, while tadalafil has a longer duration of action and may allow more flexibility around timing. Which one may be appropriate is a clinical decision.
Sildenafil is generally described as shorter-acting and is typically taken before anticipated sexual activity. Duration varies by person, dose and the specific product prescribed. Your physician will review the prescribing information for anything prescribed to you.
Tadalafil is generally described as longer-acting than sildenafil, which is why some patients consider it for flexibility around timing. Actual duration varies by individual, dose and product. Follow the prescribing information and your physician's instructions.
Onset varies by medication, dose, individual physiology and factors such as food intake. There is no universal answer, and faster onset is not automatically better. Your physician can discuss what these differences may mean for you.
Neither medication is universally better. They are different options with different characteristics, considerations and safety information. The right question is which option may be appropriate for you — and that depends on your health history, current medications and preferences.
Taking two PDE5 inhibitors on your own is not appropriate and can increase the risk of side effects. Any treatment that includes more than one active ingredient must be prescribed and directed by a physician who has evaluated you.
It refers to a customized (compounded) formulation containing more than one active ingredient — in this case tadalafil and sildenafil — prepared by a pharmacy for an individual patient when a physician determines it is medically appropriate.
No. Sildenafil and tadalafil are individually FDA-approved as separate prescription drug products. A compounded formulation combining them is not an FDA-approved combination drug product, and compounded medications are not reviewed by the FDA for safety, effectiveness or manufacturing quality in the same way. It is also not established as stronger, safer or better than either medication alone.
Sildenafil and tadalafil are prescription medications with known warnings, contraindications and possible side effects. Whether they are safe for you depends on your health, conditions and other medications, which is why a physician evaluation is required.
ED medication is not appropriate for everyone. People taking nitrates should not take these medications, and certain cardiovascular, liver, kidney, blood pressure and eye conditions — along with some drug interactions — can make treatment inappropriate. Your physician reviews this with you.
No. Combining PDE5 inhibitors with nitrate medications such as nitroglycerin or isosorbide can cause a sudden, dangerous drop in blood pressure. Tell your physician if you take nitrates in any form, including as-needed chest-pain medication.
No. PDE5 inhibitors do not raise testosterone. If hormonal factors may be contributing to your symptoms, that is evaluated separately by your physician.
No. These medications are not aphrodisiacs and do not increase libido. They support the physical erectile response when sexual stimulation is present.
Yes. Sildenafil and tadalafil are prescription medications in the United States and require evaluation by a licensed physician.
Yes. NORBU MD is a physician-led practice. There is no questionnaire-only prescribing and no automatic prescriptions — care starts with a board-certified physician.
The physician visit is $29. That fee covers the medical visit only.
No. Medication, pharmacy and laboratory costs, if applicable, are separate from the $29 visit fee.
No. The $29 visit is paid directly and does not require insurance.
Yes. Your visit and your medical information are handled confidentially as part of your medical record, and care takes place online rather than in a waiting room.
Yes. Sexual health is ongoing care. Your physician can review how treatment is going and adjust your plan when clinically appropriate.

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Why an evaluation reviews blood pressure, lipids and metabolic health before a prescription — and what that does and doesn't mean.
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Duration, timing and considerations — and why the choice belongs with a physician.
Treatment guide
Talk privately with a licensed NORBU MD physician and find out which ED treatment options may be appropriate for you.
Private · Online · Physician-led · $29 visit